By the advance on molecular biology, the technique of genetic analysis is showing the extent in the rapid force in the clinical laboratory test. However, the until now sufficient discussion on differences of attitude for genetic testing contract and discrepancy of the test data among the diagnostic facilities, came without making it. The present aim of this study is that the three major testing laboratories collaborate in constructing an advanced genetic testing system that can supply standardized data among testing facilities, for the request from customers such as clinicians. Finally, the team will introduce a unified guideline to represent all commercial gene-testing laboratories as a template system for intentional standard. The research and development period were for three years, and to begin with, in the activity of 1999 fiscal year, the existing conditions were reviewed including specimen collection, preservation, transportation, selection of anticoagulants, necessity of clinical data, evaluation methods of enzyme and other reagents, temperature calibration of equipments, sterilization and incineration methods of infectious specimens and long time storage management of DNA specimens, and the standard operational procedure was proposed.